Plenary Results — Live Sunday, May 31 · updated through the afternoon Plenary (CT)
This Weekend's Plenary: 5-for-5 on practice-changing data
LBA1
PROTEUS — perioperative apalutamide (Erleada) + ADT around prostatectomy, high-risk localized prostate cancer (J&J). Positive
Met both primary endpoints: ~9× higher pCR/MRD (8.9% vs 1.0%), 20% lower risk of metastasis or death. Published in NEJM. GU
LBA2
SARC041 — abemaciclib (Verzenio) vs placebo in advanced dedifferentiated liposarcoma (Lilly). Sarcoma — first CDK4/6 readout in this setting.
LBA3
LIBRETTO-432 — adjuvant selpercatinib (Retevmo) in resected stage IB–IIIA RET fusion+ NSCLC (Lilly). Positive EFS
Extends targeted adjuvant therapy into RET+ disease. Lung
LBA4
HARMONi-6 — ivonescimab + chemo vs tislelizumab + chemo, 1L squamous NSCLC (Akeso / Summit). Positive OS
OS HR 0.66; first China-originated drug in an ASCO Plenary. Published in The Lancet. Lung
LBA5
RASolute 302 — daraxonrasib (RAS(ON) inhibitor) vs chemo, previously-treated metastatic pancreatic cancer (Revolution Medicines, RVMD). Positive OS
Median OS 13.2 vs 6.7 mo, HR 0.40 (p<0.0001) — roughly doubled survival. Presented 3:21 PM CT; published in NEJM. GI / pancreatic
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